A blog about metabolomics, genomics, and where the two fields meet.
Posts about specific genetically influenced metabotypes, mQTLS, and more
This blog is about the new genome-wide association study (GWAS) with blood protein N-glycosylation “Defining the genetic control of human blood plasma N-glycome using genome-wide association study” by Sharapov et al. on bioRxiv. The 2012 National Research Council (US) Committee … Read More
The association of the FADS1 locus with arachidonic acid and metabolites on its pathway is one of the loci with the strongest association signal and it is a prototype for a genetically influence metabotype (GIM). Here we collect information from … Read More
We first reported an association of the NAT2 in a GWAS with NMR-derived urinary metabolites in [Suhre et al., Nature Genetics, 2011]: “On chromosome 8, SNP rs4921914 is located 14 kb downstream of and in linkage disequilibrium with the gene … Read More
The locus tagged by SNP rs272889 associates with a number of acylcarnitines, with isovalerylcarnitine (Metabolon platform) and the valine/C5 ratio (Biocrates platform) showing the strongest signals. This locus also associates with body height. NEWS: A recent paper on genome-wide patterns … Read More