A blog about metabolomics, genomics, and where the two fields meet.
This is an example for an application of The Molecular Human, drawn from our study Zaghlool et al., Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits, Nat. Comms. 2020. DNA methylation and blood circulating … Read More
A number of Covid-19 studies with metabolomics and proteomics phenotypes are currently in the making. Here I maintain a table of these studies to keep track of what has been published so far (last updated 23 March 2021. Should you … Read More
The number of association studies of DNA variation with CpG methylation – especially based on the Illumina 450k array – is steadily increasing. Quantitative trait loci for intermediate traits are particularly interesting to serve as instruments in Mendelian Randomization studies. … Read More
Here you find all published genome-wide association studies with glycomics traits (glycGWAS). If a study is missing from this list, please let me know. You may also be interested in the Table of all GWAS with Metabolomics, the Table of … Read More
This blog is about the new genome-wide association study (GWAS) with blood protein N-glycosylation “Defining the genetic control of human blood plasma N-glycome using genome-wide association study” by Sharapov et al. on bioRxiv. The 2012 National Research Council (US) Committee … Read More
UPDATE: Read our newest paper “Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation” in Human Molecular Genetics (published online on 08 Jan 2018) … full blog page coming soon! This paper focuses on 20 CpG sites … Read More
The recent perspective paper in Cell An Expanded View of Complex Traits: From Polygenic to Omnigenic [Pubmed] [Doi] by E.A. Boyle, Y. Li, and J.K. Pritchar [Cell, 15 June 2017] has sparked quite a number of discussions, as indicated by … Read More